{
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  "Title": "Diagnostics for Nonlinear Mixed-Effect Models",
  "Version": "4.7.4.9000",
  "Authors@R": "c(person(\"Andrew C.\",\"Hooker\",role=c(\"aut\",\"cre\",\"cph\"),email=\"andrew.hooker@uu.se\"),\nperson(\"Mats O.\",\"Karlsson\",role=c(\"aut\",\"cph\")),\nperson(\"Justin J.\",\"Wilkins\",role=\"aut\"),\nperson(\"E. Niclas\",\"Jonsson\",role=c(\"aut\",\"trl\",\"cph\")),\nperson(\"Ron\",\"Keizer\",role=\"ctb\",comment=\"functionality for bootstrap of GAM and SCM\"))",
  "Description": "A model building aid for nonlinear mixed-effects\n(population) model analysis using NONMEM, facilitating data set\ncheckout, exploration and visualization, model diagnostics,\ncandidate covariate identification and model comparison. The\nmethods are described in Keizer et al. (2013)\n<doi:10.1038/psp.2013.24>, and Jonsson et al. (1999)\n<doi:10.1016/s0169-2607(98)00067-4>.",
  "LazyLoad": "yes",
  "LazyData": "yes",
  "ByteCompile": "true",
  "License": "LGPL (>= 3)",
  "URL": "https://uupharmacometrics.github.io/xpose4/,\nhttps://github.com/UUPharmacometrics/xpose4",
  "BugReports": "https://github.com/UUPharmacometrics/xpose4/issues",
  "Copyright": "2009-2025 Andrew C. Hooker, E. Niclas Jonsson and Mats O.\nKarlsson. 2005-2008 Andrew C. Hooker, Justin J. Wilkins, Mats\nO. Karlsson and E. Niclas Jonsson. 1998-2004 E. Niclas Jonsson\nand Mats Karlsson.",
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  "Repository": "https://uupharmacometrics.r-universe.dev",
  "Date/Publication": "2025-09-05 11:38:42 UTC",
  "RemoteUrl": "https://github.com/uupharmacometrics/xpose4",
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    "User": "root"
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  "Author": "Andrew C. Hooker [aut, cre, cph],\nMats O. Karlsson [aut, cph],\nJustin J. Wilkins [aut],\nE. Niclas Jonsson [aut, trl, cph],\nRon Keizer [ctb] (functionality for bootstrap of GAM and SCM)",
  "Maintainer": "Andrew C. Hooker <andrew.hooker@uu.se>",
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      "concept": [
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      "page": "add_transformed_columns",
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        "add.log",
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      "page": "add.grid.table",
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      "page": "add.model.comp",
      "title": "Additional model comparison plots, for Xpose 4",
      "topics": [
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      "page": "addit.gof",
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      "page": "autocorr.cwres",
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    },
    {
      "page": "autocorr.wres",
      "title": "Autocorrelation of weighted residuals for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "autocorr.wres"
      ]
    },
    {
      "page": "basic.gof",
      "title": "Basic goodness-of-fit plots, for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "basic.gof"
      ]
    },
    {
      "page": "basic.model.comp",
      "title": "Basic model comparison plots, for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "basic.model.comp"
      ]
    },
    {
      "page": "boot.hist",
      "title": "Function to create histograms of results from the 'bootstrap' tool in PsN",
      "concept": [
        "PsN functions"
      ],
      "topics": [
        "boot.hist"
      ]
    },
    {
      "page": "bootgam.print",
      "title": "Print summary information for a bootgam or bootscm",
      "topics": [
        "bootgam.print"
      ]
    },
    {
      "page": "bootscm.import",
      "title": "Import bootscm data into R/Xpose",
      "concept": [
        "PsN functions",
        "bootscm"
      ],
      "topics": [
        "bootscm.import"
      ]
    },
    {
      "page": "cat.dv.vs.idv.sb",
      "title": "Categorical observations vs. independent variable using stacked bars.",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "cat.dv.vs.idv.sb"
      ]
    },
    {
      "page": "cat.pc",
      "title": "Categorical (visual) predictive check.",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "cat.pc"
      ]
    },
    {
      "page": "change_graphical_parameters",
      "title": "Functions changing variable definitions in Xpose 4",
      "concept": [
        "data functions"
      ],
      "topics": [
        "change.ab.graph.par",
        "change.bw.graph.par",
        "change.cond.graph.par",
        "change.dil.graph.par",
        "change.label.par",
        "change.lm.graph.par",
        "change.misc.graph.par",
        "change.pi.graph.par",
        "change.smooth.graph.par",
        "change_graphical_parameters"
      ]
    },
    {
      "page": "change_misc_parameters",
      "title": "Functions changing miscellaneous parameter settings in Xpose 4",
      "concept": [
        "data functions"
      ],
      "topics": [
        "change.cat.cont",
        "change.cat.cont<-",
        "change.cat.levels",
        "change.cat.levels<-",
        "change.dv.cat.levels",
        "change.dv.cat.levels<-",
        "change.miss",
        "change.subset",
        "change_misc_parameters",
        "get.doc",
        "set.doc"
      ]
    },
    {
      "page": "change.parm",
      "title": "Change parameter scope.",
      "topics": [
        "change.parm"
      ]
    },
    {
      "page": "change.var.name",
      "title": "Changes the name of an Xpose data item",
      "topics": [
        "change.var.name"
      ]
    },
    {
      "page": "change.xlabel",
      "title": "Changes the label of an Xpose data item",
      "topics": [
        "change.xlabel"
      ]
    },
    {
      "page": "change.xvardef",
      "title": "Change Xpose variable definitions.",
      "topics": [
        "change.xvardef",
        "change.xvardef<-"
      ]
    },
    {
      "page": "compute.cwres",
      "title": "Compute the Conditional Weighted Residuals",
      "concept": [
        "data functions"
      ],
      "topics": [
        "compute.cwres",
        "ind.cwres",
        "is.cwres.readable.file",
        "read.cwres.data",
        "sqrtm",
        "xpose.calculate.cwres"
      ]
    },
    {
      "page": "par_cov_splom",
      "title": "Plot scatterplot matrices of parameters, random parameters or covariates",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "cov.splom",
        "parm.splom",
        "par_cov_splom",
        "ranpar.splom"
      ]
    },
    {
      "page": "create.xpose.plot.classes",
      "title": "Create xpose.multiple.plot class.",
      "topics": [
        "create.xpose.plot.classes",
        "print,xpose.multiple.plot-method"
      ]
    },
    {
      "page": "createXposeClasses",
      "title": "This function creates the Xpose data classes (\"xpose.data\" and \"xpose.prefs\")",
      "topics": [
        "createXposeClasses"
      ]
    },
    {
      "page": "cwres.dist.hist",
      "title": "Histogram of conditional weighted residuals (CWRES), for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "cwres.dist.hist"
      ]
    },
    {
      "page": "cwres.dist.qq",
      "title": "Quantile-quantile plot of conditional weighted residuals (CWRES), for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "cwres.dist.qq"
      ]
    },
    {
      "page": "cwres.vs.cov",
      "title": "Conditional Weighted residuals (CWRES) plotted against covariates, for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "cwres.vs.cov"
      ]
    },
    {
      "page": "cwres.vs.idv",
      "title": "Population conditional weighted residuals (CWRES) plotted against the independent variable (IDV) for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "cwres.vs.idv"
      ]
    },
    {
      "page": "cwres.vs.idv.bw",
      "title": "Box-and-whisker plot of conditional weighted residuals vs the independent variable for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "cwres.vs.idv.bw"
      ]
    },
    {
      "page": "cwres.vs.pred",
      "title": "Population conditional weighted residuals (CWRES) plotted against population predictions (PRED) for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "cwres.vs.pred"
      ]
    },
    {
      "page": "cwres.vs.pred.bw",
      "title": "Box-and-whisker plot of conditional weighted residuals vs population predictions for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "cwres.vs.pred.bw"
      ]
    },
    {
      "page": "cwres.wres.vs.idv",
      "title": "Weighted residuals (WRES) and conditional WRES (CWRES) plotted against the independent variable (IDV)",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "cwres.wres.vs.idv"
      ]
    },
    {
      "page": "cwres.wres.vs.pred",
      "title": "Weighted residuals (WRES) and conditional WRES (CWRES) plotted against the population predictions (PRED)",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "cwres.wres.vs.pred"
      ]
    },
    {
      "page": "data_extract_or_assign",
      "title": "Extract or assign data from an xpose.data object.",
      "concept": [
        "data functions"
      ],
      "topics": [
        "Data",
        "Data<-",
        "data_extract_or_assign",
        "SData",
        "SData<-"
      ]
    },
    {
      "page": "data.checkout",
      "title": "Check through the source dataset to detect problems",
      "concept": [
        "data functions",
        "specific functions"
      ],
      "topics": [
        "data.checkout"
      ]
    },
    {
      "page": "db.names",
      "title": "Prints the contents of an Xpose data object",
      "concept": [
        "data functions"
      ],
      "topics": [
        "db.names"
      ]
    },
    {
      "page": "dOFV.vs.cov",
      "title": "Change in individual objective function value vs. covariate value.",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "dOFV.vs.cov"
      ]
    },
    {
      "page": "dOFV.vs.id",
      "title": "Change in Objective function value vs. removal of individuals.",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "dOFV.vs.id"
      ]
    },
    {
      "page": "dOFV1.vs.dOFV2",
      "title": "Change in individual objective function value 1 vs. individual objective function value 2.",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "dOFV1.vs.dOFV2"
      ]
    },
    {
      "page": "dv.preds.vs.idv",
      "title": "Observations (DV), individual predictions (IPRED) and population predictions (IPRED) plotted against the independent variable (IDV), for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "dv.preds.vs.idv"
      ]
    },
    {
      "page": "dv.vs.idv",
      "title": "Observations (DV) plotted against the independent variable (IDV) for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "dv.vs.idv"
      ]
    },
    {
      "page": "dv.vs.ipred",
      "title": "Observations (DV) plotted against individual predictions (IPRED) for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "dv.vs.ipred"
      ]
    },
    {
      "page": "dv.vs.ipred.by.cov",
      "title": "Dependent variable vs individual predictions, conditioned on covariates, for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "dv.vs.ipred.by.cov"
      ]
    },
    {
      "page": "dv.vs.ipred.by.idv",
      "title": "Dependent variable vs individual predictions, conditioned on independent variable, for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "dv.vs.ipred.by.idv"
      ]
    },
    {
      "page": "dv.vs.pred",
      "title": "Observations (DV) plotted against population predictions (PRED) for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "dv.vs.pred"
      ]
    },
    {
      "page": "dv.vs.pred.by.cov",
      "title": "Dependent variable vs population predictions, conditioned on covariates, for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "dv.vs.pred.by.cov"
      ]
    },
    {
      "page": "dv.vs.pred.by.idv",
      "title": "Dependent variable vs population predictions, conditioned on independent variable, for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "dv.vs.pred.by.idv"
      ]
    },
    {
      "page": "dv.vs.pred.ipred",
      "title": "Observations (DV) are plotted against individual predictions (IPRED) and population predictions (PRED), for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "dv.vs.pred.ipred"
      ]
    },
    {
      "page": "export.graph.par",
      "title": "Exports Xpose graphics settings to a file.",
      "concept": [
        "data functions"
      ],
      "topics": [
        "export.graph.par",
        "xpose.write"
      ]
    },
    {
      "page": "export.variable.definitions",
      "title": "Exports Xpose variable definitions to a file from an Xpose data object.",
      "concept": [
        "data functions"
      ],
      "topics": [
        "export.variable.definitions"
      ]
    },
    {
      "page": "GAM_summary_and_plot",
      "title": "GAM functions for Xpose 4",
      "concept": [
        "GAM functions"
      ],
      "topics": [
        "GAM_summary_and_plot",
        "xp.akaike.plot",
        "xp.cook",
        "xp.ind.inf.fit",
        "xp.ind.inf.terms",
        "xp.ind.stud.res",
        "xp.plot",
        "xp.summary"
      ]
    },
    {
      "page": "gof",
      "title": "Structured goodness of fit diagnostics.",
      "concept": [
        "generic functions",
        "specific functions"
      ],
      "topics": [
        "gof",
        "gofSetup",
        "xpPage"
      ]
    },
    {
      "page": "import.graph.par",
      "title": "Imports Xpose graphics settings from a file to an Xpose data object.",
      "concept": [
        "data functions"
      ],
      "topics": [
        "import.graph.par",
        "xpose.read"
      ]
    },
    {
      "page": "import.variable.definitions",
      "title": "Imports Xpose variable definitions from a file to an Xpose data object.",
      "concept": [
        "data functions"
      ],
      "topics": [
        "import.variable.definitions"
      ]
    },
    {
      "page": "ind.plots",
      "title": "Observations (DV), individual predictions (IPRED) and population predictions (PRED) are plotted against the independent variable for every individual in the dataset, for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "ind.plots"
      ]
    },
    {
      "page": "ind.plots.wres.hist",
      "title": "Histograms of weighted residuals for each individual in an Xpose data object, for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "ind.plots.cwres.hist",
        "ind.plots.wres.hist"
      ]
    },
    {
      "page": "ind.plots.wres.qq",
      "title": "Quantile-quantile plots of weighted residuals for each individual in an Xpose data object, for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "ind.plots.cwres.qq",
        "ind.plots.wres.qq"
      ]
    },
    {
      "page": "ipred.vs.idv",
      "title": "Individual predictions (IPRED) plotted against the independent variable (IDV) for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "ipred.vs.idv"
      ]
    },
    {
      "page": "iwres.dist.hist",
      "title": "Histogram of individual weighted residuals (IWRES), for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "iwres.dist.hist"
      ]
    },
    {
      "page": "iwres.dist.qq",
      "title": "Quantile-quantile plot of individual weighted residuals (IWRES), for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "iwres.dist.qq"
      ]
    },
    {
      "page": "iwres.vs.idv",
      "title": "Individual weighted residuals (IWRES) plotted against the independent variable (IDV) for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "iwres.vs.idv"
      ]
    },
    {
      "page": "kaplan.plot",
      "title": "Kaplan-Meier plots of (repeated) time-to-event data",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "kaplan.plot"
      ]
    },
    {
      "page": "make.sb.data",
      "title": "Make stacked bar data set.",
      "concept": [
        "data functions"
      ],
      "topics": [
        "make.sb.data"
      ]
    },
    {
      "page": "npc.coverage",
      "title": "Function to plot the coverage of the Numerical Predictive Check",
      "concept": [
        "PsN functions"
      ],
      "topics": [
        "npc.coverage"
      ]
    },
    {
      "page": "nsim",
      "title": "Extract or set the value of the Nsim slot.",
      "concept": [
        "data functions"
      ],
      "topics": [
        "nsim",
        "nsim<-"
      ]
    },
    {
      "page": "par_cov_hist",
      "title": "Plot the parameter or covariate distributions using a histogram",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "cov.hist",
        "parm.hist",
        "par_cov_hist",
        "ranpar.hist"
      ]
    },
    {
      "page": "par_cov_qq",
      "title": "Plot the parameter or covariate distributions using quantile-quantile (Q-Q) plots",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "cov.qq",
        "parm.qq",
        "par_cov_qq",
        "ranpar.qq"
      ]
    },
    {
      "page": "par_cov_summary",
      "title": "Summarize individual parameter values and covariates",
      "concept": [
        "data functions"
      ],
      "topics": [
        "cov.summary",
        "parm.summary",
        "par_cov_summary"
      ]
    },
    {
      "page": "parm.vs.cov",
      "title": "Parameters plotted against covariates, for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "parm.vs.cov"
      ]
    },
    {
      "page": "parm.vs.parm",
      "title": "Plot parameters vs other parameters",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "parm.vs.parm"
      ]
    },
    {
      "page": "pred.vs.idv",
      "title": "Population predictions (PRED) plotted against the independent variable (IDV) for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "pred.vs.idv"
      ]
    },
    {
      "page": "print.xpose.multiple.plot",
      "title": "Print an Xpose multiple plot object.",
      "topics": [
        "print.xpose.multiple.plot"
      ]
    },
    {
      "page": "randtest.hist",
      "title": "Function to create a histogram of results from the randomization test tool ('randtest') in PsN",
      "concept": [
        "PsN functions"
      ],
      "topics": [
        "randtest.hist"
      ]
    },
    {
      "page": "ranpar.vs.cov",
      "title": "Random parameters plotted against covariates, for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "ranpar.vs.cov"
      ]
    },
    {
      "page": "read_NM_output",
      "title": "Read NONMEM output files into Xpose 4",
      "concept": [
        "data functions"
      ],
      "topics": [
        "calc.npar",
        "create.parameter.list",
        "read.lst",
        "read_NM_output"
      ]
    },
    {
      "page": "read_nm_table",
      "title": "Read NONMEM table files produced from simulation.",
      "concept": [
        "data functions"
      ],
      "topics": [
        "read_nm_table"
      ]
    },
    {
      "page": "read.nm.tables",
      "title": "Reading NONMEM table files",
      "concept": [
        "data functions"
      ],
      "topics": [
        "read.nm.tables"
      ]
    },
    {
      "page": "read.npc.vpc.results",
      "title": "Read the results file from a Numerical or Visual Predictive Check run in PsN",
      "concept": [
        "PsN functions"
      ],
      "topics": [
        "read.npc.vpc.results"
      ]
    },
    {
      "page": "read.TTE.sim.data",
      "title": "Read (repeated) time-to-event simulation data files.",
      "concept": [
        "data functions"
      ],
      "topics": [
        "read.TTE.sim.data"
      ]
    },
    {
      "page": "read.vpctab",
      "title": "Read the vpctab file from PsN into Xpose",
      "concept": [
        "PsN functions"
      ],
      "topics": [
        "read.vpctab"
      ]
    },
    {
      "page": "reset.graph.par",
      "title": "Resets Xpose variable definitions to factory settings",
      "topics": [
        "reset.graph.par"
      ]
    },
    {
      "page": "runsum",
      "title": "Print run summary in Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "runsum"
      ]
    },
    {
      "page": "simpraz.xpdb",
      "title": "Simulated prazosin Xpose database.",
      "topics": [
        "simpraz.xpdb"
      ]
    },
    {
      "page": "simprazExample",
      "title": "Function to create files for the simulated prazosin example in Xpose",
      "concept": [
        "data functions"
      ],
      "topics": [
        "simprazExample"
      ]
    },
    {
      "page": "tabulate.parameters",
      "title": "Tabulate the population parameter estimates",
      "concept": [
        "data functions"
      ],
      "topics": [
        "tabulate.parameters"
      ]
    },
    {
      "page": "wres.dist.hist",
      "title": "Histogram of weighted residuals (WRES), for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "wres.dist.hist"
      ]
    },
    {
      "page": "wres.dist.qq",
      "title": "Quantile-quantile plot of weighted residuals (WRES), for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "wres.dist.qq"
      ]
    },
    {
      "page": "wres.vs.cov",
      "title": "Weighted residuals (WRES) plotted against covariates, for Xpose 4",
      "topics": [
        "wres.vs.cov"
      ]
    },
    {
      "page": "wres.vs.idv",
      "title": "Population weighted residuals (WRES) plotted against the independent variable (IDV) for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "wres.vs.idv"
      ]
    },
    {
      "page": "wres.vs.idv.bw",
      "title": "Box-and-whisker plot of weighted residuals vs the independent variable for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "wres.vs.idv.bw"
      ]
    },
    {
      "page": "wres.vs.pred",
      "title": "Population weighted residuals (WRES) plotted against population predictions (PRED) for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "wres.vs.pred"
      ]
    },
    {
      "page": "wres.vs.pred.bw",
      "title": "Box-and-whisker plot of weighted residuals vs population predictions for Xpose 4",
      "concept": [
        "specific functions"
      ],
      "topics": [
        "wres.vs.pred.bw"
      ]
    },
    {
      "page": "xlabel",
      "title": "Extract and set labels for Xpose data items.",
      "concept": [
        "data functions"
      ],
      "topics": [
        "xlabel",
        "xlabel<-"
      ]
    },
    {
      "page": "xp.boot.par.est",
      "title": "Compare parameter estimates for covariate coefficients",
      "topics": [
        "xp.boot.par.est"
      ]
    },
    {
      "page": "xp.boot.par.est.corr",
      "title": "Correlations between covariate coefficients",
      "topics": [
        "xp.boot.par.est.corr"
      ]
    },
    {
      "page": "xp.daic.npar.plot",
      "title": "Distribution of difference in AIC",
      "concept": [
        "bootgam",
        "bootscm"
      ],
      "topics": [
        "xp.daic.npar.plot"
      ]
    },
    {
      "page": "xp.distr.mod.size",
      "title": "Plot of model size distribution for a bootgam or bootscm",
      "topics": [
        "xp.distr.mod.size"
      ]
    },
    {
      "page": "xp.dofv.npar.plot",
      "title": "Distribution of difference in OFV",
      "concept": [
        "bootgam",
        "bootscm"
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      "title": "OFV difference (optimism) plot.",
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      "title": "Inclusion stability plot A plot of the inclusion frequency of covariates vs bootgam/bootscm iteration number. This plot can be used to evaluate whether sufficient iterations have been performed.",
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