{
  "_id": "6a4968313c3572b93bf7f93f",
  "Package": "ncappc",
  "Title": "NCA Calculations and Population Model Diagnosis",
  "Version": "1.0.0.9000",
  "Authors@R": "c(\nperson(\"Chayan\", \"Acharya\", role = \"aut\"),\nperson(\"Gulbeyaz Y.\", \"Turkyilmaz\", role = \"aut\"),\nperson(\"Siv\", \"Jonsson\", role = \"aut\"),\nperson(\"Mats O.\", \"Karlsson\", role = \"aut\"),\nperson(\"Andrew C.\",\"Hooker\", email=\"andrew.hooker@uu.se\",\nrole=c(\"aut\",\"cre\"),\ncomment=c(ORCID = \"0000-0002-2676-5912\")\n))",
  "Description": "A flexible tool that can perform (i) traditional\nnon-compartmental analysis (NCA) and (ii) Simulation-based\nposterior predictive checks for population pharmacokinetic (PK)\nand/or pharmacodynamic (PKPD) models using NCA metrics. The\nmethods are described in Acharya et al. (2016)\n<doi:10.1016/j.cmpb.2016.01.013>.",
  "License": "GPL-3",
  "VignetteBuilder": "knitr",
  "RoxygenNote": "7.3.2",
  "Encoding": "UTF-8",
  "URL": "https://github.com/UUPharmacometrics/ncappc,\nhttps://uupharmacometrics.github.io/ncappc/",
  "BugReports": "https://github.com/UUPharmacometrics/ncappc/issues",
  "Config/pak/sysreqs": "cmake make libicu-dev libuv1-dev libx11-dev",
  "Repository": "https://uupharmacometrics.r-universe.dev",
  "Date/Publication": "2025-04-25 15:10:38 UTC",
  "RemoteUrl": "https://github.com/uupharmacometrics/ncappc",
  "RemoteRef": "HEAD",
  "RemoteSha": "071bb256d8057ef9934e5dbd88d7d0b27705acf8",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-06-23 08:11:51 UTC",
    "User": "root"
  },
  "Author": "Chayan Acharya [aut],\nGulbeyaz Y. Turkyilmaz [aut],\nSiv Jonsson [aut],\nMats O. Karlsson [aut],\nAndrew C. Hooker [aut, cre] (ORCID:\n<https://orcid.org/0000-0002-2676-5912>)",
  "Maintainer": "Andrew C. Hooker <andrew.hooker@uu.se>",
  "_user": "uupharmacometrics",
  "_type": "src",
  "_file": "ncappc_1.0.0.9000.tar.gz",
  "_fileid": "https://r2.ropensci.org/5a3dc672e3728b9fc0c2951b27f9fa7e04e11b5d7346df235feb13f99d9a642f",
  "_filesize": 3894428,
  "_sha256": "5a3dc672e3728b9fc0c2951b27f9fa7e04e11b5d7346df235feb13f99d9a642f",
  "_expires": "2026-10-12T20:08:14.000Z",
  "_created": "2026-06-23T08:11:51.000Z",
  "_published": "2026-07-04T20:08:17.068Z",
  "_jobs": [
    {
      "job": 85163128369,
      "time": 161,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "OK",
      "artifact": "7815130120"
    },
    {
      "job": 85163128417,
      "time": 157,
      "config": "linux-release-x86_64",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7815128740"
    },
    {
      "job": 85163128528,
      "time": 150,
      "config": "macos-oldrel-arm64",
      "r": "4.5.3",
      "check": "OK",
      "artifact": "7815116026"
    },
    {
      "job": 85163128585,
      "time": 135,
      "config": "macos-release-arm64",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7815113458"
    },
    {
      "job": 85163128213,
      "time": 202,
      "config": "source",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7815068284"
    },
    {
      "job": 85163128486,
      "time": 126,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7815116323"
    },
    {
      "job": 85163128493,
      "time": 111,
      "config": "windows-devel",
      "r": "4.7.0",
      "check": "OK",
      "artifact": "7815111525"
    },
    {
      "job": 85163128608,
      "time": 120,
      "config": "windows-oldrel",
      "r": "4.5.3",
      "check": "OK",
      "artifact": "7815116824"
    },
    {
      "job": 85163128562,
      "time": 117,
      "config": "windows-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7815114379"
    }
  ],
  "_host": "GitHub-Actions",
  "_buildurl": "https://github.com/r-universe/uupharmacometrics/actions/runs/28011857672",
  "_status": "success",
  "_upstream": "https://github.com/uupharmacometrics/ncappc",
  "_commit": {
    "id": "071bb256d8057ef9934e5dbd88d7d0b27705acf8",
    "author": "Andrew Hooker <andrew.c.hooker@gmail.com>",
    "committer": "Andrew Hooker <andrew.c.hooker@gmail.com>",
    "message": "Increment version number to 1.0.0.9000\n",
    "time": 1745593838
  },
  "_maintainer": {
    "name": "Andrew C. Hooker",
    "email": "andrew.hooker@uu.se",
    "login": "andrewhooker",
    "orcid": "0000-0002-2676-5912",
    "description": "",
    "uuid": 5432932
  },
  "_distro": "noble",
  "_registered": true,
  "_dependencies": [
    {
      "package": "R",
      "version": ">= 2.15.3",
      "role": "Depends"
    },
    {
      "package": "scales",
      "role": "Imports"
    },
    {
      "package": "gtable",
      "role": "Imports"
    },
    {
      "package": "knitr",
      "role": "Imports"
    },
    {
      "package": "xtable",
      "role": "Imports"
    },
    {
      "package": "reshape2",
      "role": "Imports"
    },
    {
      "package": "dplyr",
      "role": "Imports"
    },
    {
      "package": "readr",
      "version": ">= 0.2.2",
      "role": "Imports"
    },
    {
      "package": "lazyeval",
      "role": "Imports"
    },
    {
      "package": "PopED",
      "role": "Imports"
    },
    {
      "package": "magrittr",
      "role": "Imports"
    },
    {
      "package": "rlang",
      "role": "Imports"
    },
    {
      "package": "purrr",
      "role": "Imports"
    },
    {
      "package": "tibble",
      "role": "Imports"
    },
    {
      "package": "rmarkdown",
      "role": "Imports"
    },
    {
      "package": "tidyr",
      "role": "Imports"
    },
    {
      "package": "ggplot2",
      "version": ">= 2.0.0",
      "role": "Imports"
    },
    {
      "package": "grid",
      "role": "Imports"
    },
    {
      "package": "gridExtra",
      "version": ">= 2.0.0",
      "role": "Imports"
    },
    {
      "package": "grDevices",
      "role": "Imports"
    },
    {
      "package": "stats",
      "role": "Imports"
    },
    {
      "package": "bookdown",
      "role": "Imports"
    },
    {
      "package": "testthat",
      "role": "Suggests"
    }
  ],
  "_owner": "uupharmacometrics",
  "_selfowned": true,
  "_usedby": 0,
  "_updates": [],
  "_tags": [],
  "_stars": 17,
  "_contributors": [
    {
      "user": "andrewhooker",
      "count": 143,
      "uuid": 5432932
    },
    {
      "user": "cacha0227",
      "count": 91,
      "uuid": 9989646
    },
    {
      "user": "rikardn",
      "count": 1,
      "uuid": 12795317
    }
  ],
  "_userbio": {
    "uuid": 23479164,
    "type": "organization",
    "name": "Uppsala University, Pharmacometrics Research Group",
    "followers": 64
  },
  "_downloads": {
    "count": 389,
    "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/ncappc"
  },
  "_mentions": 1,
  "_devurl": "https://github.com/uupharmacometrics/ncappc",
  "_pkgdown": "https://uupharmacometrics.github.io/ncappc/",
  "_searchresults": 25,
  "_rbuild": "4.6.0",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/ncappc.html",
    "extra/NEWS.html",
    "extra/NEWS.txt",
    "extra/readme.html",
    "extra/readme.md",
    "manual.pdf"
  ],
  "_homeurl": "https://github.com/uupharmacometrics/ncappc",
  "_realowner": "uupharmacometrics",
  "_cranurl": true,
  "_releases": [
    {
      "version": "0.1",
      "date": "2015-03-04"
    },
    {
      "version": "0.2",
      "date": "2015-07-16"
    },
    {
      "version": "0.2.1.0",
      "date": "2015-12-08"
    },
    {
      "version": "0.2.1.1",
      "date": "2016-02-17"
    },
    {
      "version": "0.3.0",
      "date": "2018-08-24"
    },
    {
      "version": "1.0.0",
      "date": "2025-04-25"
    }
  ],
  "_exports": [
    "calc.stat",
    "dv.plot",
    "est.nca",
    "histobs.plot",
    "histpop.plot",
    "nca.check.obs",
    "nca.check.sim",
    "nca.deviation.plot",
    "nca.ind.data",
    "nca.npde",
    "nca.npde.plot",
    "nca.pde.deviation.outlier",
    "nca.read.sim",
    "ncappc",
    "out.digits",
    "read_nm_table"
  ],
  "_help": [
    {
      "page": "calc.stat",
      "title": "Calculates a set of statistics for a given array of numbers.",
      "topics": [
        "calc.stat"
      ]
    },
    {
      "page": "dv.plot",
      "title": "Plots drug plasma concentration vs time data",
      "topics": [
        "dv.plot"
      ]
    },
    {
      "page": "est.nca",
      "title": "Estimate individual NCA metrics.",
      "topics": [
        "est.nca"
      ]
    },
    {
      "page": "histobs.plot",
      "title": "Plots histogram of selected set of NCA metrics.",
      "topics": [
        "histobs.plot"
      ]
    },
    {
      "page": "histpop.plot",
      "title": "Plots population histogram of the NCA metrics selected for model diagnosis.",
      "topics": [
        "histpop.plot"
      ]
    },
    {
      "page": "nca_ind_data",
      "title": "Prepare individual PK data",
      "topics": [
        "nca_ind_data"
      ]
    },
    {
      "page": "nca.check.obs",
      "title": "Check observed data",
      "topics": [
        "nca.check.obs"
      ]
    },
    {
      "page": "nca.check.sim",
      "title": "Check simulated data",
      "topics": [
        "nca.check.sim"
      ]
    },
    {
      "page": "nca.deviation.plot",
      "title": "Plot individual deviation of NCA metrics estimated from observed and simulated data",
      "topics": [
        "nca.deviation.plot"
      ]
    },
    {
      "page": "nca.ind.data",
      "title": "Prepare individual PK data",
      "topics": [
        "nca.ind.data"
      ]
    },
    {
      "page": "nca.npde",
      "title": "Calculates individual normalized prediction distribution errors (NPDE) from PDE data.",
      "topics": [
        "nca.npde"
      ]
    },
    {
      "page": "nca.npde.plot",
      "title": "Plots population histogram of the NCA metrics selected for model diagnosis.",
      "topics": [
        "nca.npde.plot"
      ]
    },
    {
      "page": "nca.pde.deviation.outlier",
      "title": "Calculates individual prediction distribution errors (PDE) and scaled deviation of NCA metrics estimated from observed and simulated data. Identifies outlier to population PK model.",
      "topics": [
        "nca.pde.deviation.outlier"
      ]
    },
    {
      "page": "nca.read.sim",
      "title": "Check observed data",
      "topics": [
        "nca.read.sim"
      ]
    },
    {
      "page": "ncappc",
      "title": "Performs NCA calculations and population PK model diagnosis.",
      "topics": [
        "ncappc"
      ]
    },
    {
      "page": "out.digits",
      "title": "output value with correct digits and trailing zero",
      "topics": [
        "out.digits"
      ]
    },
    {
      "page": "read_nm_table",
      "title": "Read NONMEM table files produced.",
      "topics": [
        "read_nm_table"
      ]
    }
  ],
  "_readme": "https://github.com/uupharmacometrics/ncappc/raw/HEAD/README.md",
  "_rundeps": [
    "base64enc",
    "bit",
    "bit64",
    "bookdown",
    "boot",
    "bslib",
    "cachem",
    "cli",
    "clipr",
    "codetools",
    "cpp11",
    "crayon",
    "digest",
    "dplyr",
    "evaluate",
    "farver",
    "fastmap",
    "fontawesome",
    "fs",
    "generics",
    "ggplot2",
    "glue",
    "gridExtra",
    "gtable",
    "gtools",
    "highr",
    "hms",
    "htmltools",
    "isoband",
    "jquerylib",
    "jsonlite",
    "knitr",
    "labeling",
    "lazyeval",
    "lifecycle",
    "magrittr",
    "MASS",
    "memoise",
    "mime",
    "mvtnorm",
    "pillar",
    "pkgconfig",
    "plyr",
    "PopED",
    "prettyunits",
    "progress",
    "purrr",
    "R6",
    "rappdirs",
    "RColorBrewer",
    "Rcpp",
    "readr",
    "reshape2",
    "rlang",
    "rmarkdown",
    "S7",
    "sass",
    "scales",
    "stringi",
    "stringr",
    "tibble",
    "tidyr",
    "tidyselect",
    "tinytex",
    "tzdb",
    "utf8",
    "vctrs",
    "viridisLite",
    "vroom",
    "withr",
    "xfun",
    "xtable",
    "yaml"
  ],
  "_vignettes": [
    {
      "source": "ncappc-vignette.Rmd",
      "filename": "ncappc-vignette.html",
      "title": "Introduction to the ncappc package",
      "author": "Chayan Acharya, Andrew C. Hooker, Siv Jönsson, Mats O. Karlsson",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Introduction",
        "Estimated NCA metrics",
        "Estimation method",
        "Output",
        "Tabular output",
        "ncaOutput.tsv",
        "ObsStat.tsv",
        "SimStat.tsv",
        "ncaSimData.tsv",
        "ncaSimEst.tsv",
        "Graphical output",
        "[Individual level] Concentration vs. time profile",
        "[Population level] Histogram of the selected NCA metrics estimated from the observed data",
        "[Population level] Histogram of the simulated population means of the NCA metrics",
        "[Individual level] Deviation of the simulated NCA metrics from the observed value",
        "[Individual level] Distribution of the simulated NCA metrics for the outliers}",
        "[Population level] Histogram of the NPDE values of the NCA metrics within a given population group",
        "[Population level] Forest plot for the NPDE type analysis",
        "[Individual level] NPDE values of the NCA metrics for each individual"
      ],
      "created": "2015-02-25 10:06:09",
      "modified": "2018-06-07 08:45:28",
      "commits": 11
    }
  ],
  "_score": 5.628388930050312,
  "_indexed": true,
  "_nocasepkg": "ncappc",
  "_universes": [
    "uupharmacometrics",
    "andrewhooker"
  ],
  "_binaries": [
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "1.0.0.9000",
      "date": "2026-06-23T08:14:11.000Z",
      "distro": "noble",
      "commit": "071bb256d8057ef9934e5dbd88d7d0b27705acf8",
      "fileid": "https://r2.ropensci.org/fa55d16ef2c7548e5e5ee71dd5d9297ccf2a9aa606c241458b5fe6610f7dc96c",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/uupharmacometrics/actions/runs/28011857672"
    },
    {
      "r": "4.6.0",
      "os": "linux",
      "version": "1.0.0.9000",
      "date": "2026-06-23T08:14:09.000Z",
      "distro": "noble",
      "commit": "071bb256d8057ef9934e5dbd88d7d0b27705acf8",
      "fileid": "https://r2.ropensci.org/795ec56623a5d992661b2d0922404ad850ead00a0a933555bbeea7963560f961",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/uupharmacometrics/actions/runs/28011857672"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "1.0.0.9000",
      "date": "2026-06-23T08:13:53.000Z",
      "commit": "071bb256d8057ef9934e5dbd88d7d0b27705acf8",
      "fileid": "https://r2.ropensci.org/be30e4ca271d95b75ccd1732767e5f484adc52a36e01e4348b7a40eaae392056",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/uupharmacometrics/actions/runs/28011857672"
    },
    {
      "r": "4.6.0",
      "os": "mac",
      "version": "1.0.0.9000",
      "date": "2026-06-23T08:13:45.000Z",
      "commit": "071bb256d8057ef9934e5dbd88d7d0b27705acf8",
      "fileid": "https://r2.ropensci.org/5df7580eaf754969f70caefbc6b97f9f2507cdb7079dbb9d4a41eaa39ba233fe",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/uupharmacometrics/actions/runs/28011857672"
    },
    {
      "r": "4.6.0",
      "os": "wasm",
      "version": "1.0.0.9000",
      "date": "2026-06-23T08:14:16.000Z",
      "commit": "071bb256d8057ef9934e5dbd88d7d0b27705acf8",
      "fileid": "https://r2.ropensci.org/a81046c0c6c209e7f17c361bf89d7038adf6a773c54e7a657fcad4b5f8b8f32d",
      "status": "success",
      "buildurl": "https://github.com/r-universe/uupharmacometrics/actions/runs/28011857672"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "1.0.0.9000",
      "date": "2026-06-23T08:13:13.000Z",
      "commit": "071bb256d8057ef9934e5dbd88d7d0b27705acf8",
      "fileid": "https://r2.ropensci.org/3eabdca5462b4048cf0d3ba4bdf78d7b4b03d6506c96c59d5b0c20c9fbe8314a",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/uupharmacometrics/actions/runs/28011857672"
    },
    {
      "r": "4.5.3",
      "os": "win",
      "version": "1.0.0.9000",
      "date": "2026-06-23T08:13:30.000Z",
      "commit": "071bb256d8057ef9934e5dbd88d7d0b27705acf8",
      "fileid": "https://r2.ropensci.org/a597e6bb7bc077c2303a5aa06a5fe55a679496534c3941bed2220b4064376b97",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/uupharmacometrics/actions/runs/28011857672"
    },
    {
      "r": "4.6.0",
      "os": "win",
      "version": "1.0.0.9000",
      "date": "2026-06-23T08:13:18.000Z",
      "commit": "071bb256d8057ef9934e5dbd88d7d0b27705acf8",
      "fileid": "https://r2.ropensci.org/d621bb1dd16373725ea5ad5e897b9f10fc9df06a7d3a63ed6bd2e1fb95f0db69",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/uupharmacometrics/actions/runs/28011857672"
    }
  ]
}