{ "_id": "6a12b498acfb0bcc41d1a958", "Package": "ncappc", "Title": "NCA Calculations and Population Model Diagnosis", "Version": "1.0.0.9000", "Authors@R": "c(\nperson(\"Chayan\", \"Acharya\", role = \"aut\"),\nperson(\"Gulbeyaz Y.\", \"Turkyilmaz\", role = \"aut\"),\nperson(\"Siv\", \"Jonsson\", role = \"aut\"),\nperson(\"Mats O.\", \"Karlsson\", role = \"aut\"),\nperson(\"Andrew C.\",\"Hooker\", email=\"andrew.hooker@uu.se\",\nrole=c(\"aut\",\"cre\"),\ncomment=c(ORCID = \"0000-0002-2676-5912\")\n))", "Description": "A flexible tool that can perform (i) traditional\nnon-compartmental analysis (NCA) and (ii) Simulation-based\nposterior predictive checks for population pharmacokinetic (PK)\nand/or pharmacodynamic (PKPD) models using NCA metrics. The\nmethods are described in Acharya et al. (2016)\n.", "License": "GPL-3", "VignetteBuilder": "knitr", "RoxygenNote": "7.3.2", "Encoding": "UTF-8", "URL": "https://github.com/UUPharmacometrics/ncappc,\nhttps://uupharmacometrics.github.io/ncappc/", "BugReports": "https://github.com/UUPharmacometrics/ncappc/issues", "Config/pak/sysreqs": "cmake make libicu-dev libuv1-dev libx11-dev", "Repository": "https://uupharmacometrics.r-universe.dev", "Date/Publication": "2025-04-25 15:10:38 UTC", "RemoteUrl": "https://github.com/uupharmacometrics/ncappc", "RemoteRef": "HEAD", "RemoteSha": "071bb256d8057ef9934e5dbd88d7d0b27705acf8", "NeedsCompilation": "no", "Packaged": { "Date": "2026-05-24 08:15:58 UTC", "User": "root" }, "Author": "Chayan Acharya [aut],\nGulbeyaz Y. Turkyilmaz [aut],\nSiv Jonsson [aut],\nMats O. Karlsson [aut],\nAndrew C. Hooker [aut, cre] (ORCID:\n)", "Maintainer": "Andrew C. Hooker ", "MD5sum": "10c734b48998f23a2fdc18569354aecb", "_user": "uupharmacometrics", "_type": "src", "_file": "ncappc_1.0.0.9000.tar.gz", "_fileid": "bdb7385f440d46a5c31bc652b3b1d3f610d06e4771707db6e2cc020c25b69b79", "_filesize": 3894592, "_sha256": "bdb7385f440d46a5c31bc652b3b1d3f610d06e4771707db6e2cc020c25b69b79", "_created": "2026-05-24T08:15:58.000Z", "_published": "2026-05-24T08:19:36.776Z", "_distro": "noble", "_jobs": [ { "job": 77583047152, "time": 165, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "7183591184" }, { "job": 77583047123, "time": 171, "config": "linux-release-x86_64", "r": "4.6.0", "check": "OK", "artifact": "7183591695" }, { "job": 77583047127, "time": 136, "config": "macos-oldrel-arm64", "r": "4.5.3", "check": "OK", "artifact": "7183586298" }, { "job": 77583047126, "time": 167, "config": "macos-release-arm64", "r": "4.6.0", "check": "OK", "artifact": "7183588661" }, { "job": 77582838950, "time": 220, "config": "source", "r": "4.6.0", "check": "OK", "artifact": "7183573611" }, { "job": 77583047113, "time": 154, "config": "wasm-release", "r": "4.6.0", "check": "OK", "artifact": "7183589822" }, { "job": 77583047143, "time": 113, "config": "windows-devel", "r": "4.7.0", "check": "OK", "artifact": "7183585810" }, { "job": 77583047139, "time": 111, "config": "windows-oldrel", "r": "4.5.3", "check": "OK", "artifact": "7183585525" }, { "job": 77583047150, "time": 103, "config": "windows-release", "r": "4.6.0", "check": "OK", "artifact": "7183584753" } ], "_buildurl": "https://github.com/r-universe/uupharmacometrics/actions/runs/26356039488", "_status": "success", "_host": "GitHub-Actions", "_upstream": "https://github.com/uupharmacometrics/ncappc", "_commit": { "id": "071bb256d8057ef9934e5dbd88d7d0b27705acf8", "author": "Andrew Hooker ", "committer": "Andrew Hooker ", "message": "Increment version number to 1.0.0.9000\n", "time": 1745593838 }, "_maintainer": { "name": "Andrew C. Hooker", "email": "andrew.hooker@uu.se", "login": "andrewhooker", "orcid": "0000-0002-2676-5912", "description": "", "uuid": 5432932 }, "_registered": true, "_dependencies": [ { "package": "R", "version": ">= 2.15.3", "role": "Depends" }, { "package": "scales", "role": "Imports" }, { "package": "gtable", "role": "Imports" }, { "package": "knitr", "role": "Imports" }, { "package": "xtable", "role": "Imports" }, { "package": "reshape2", "role": "Imports" }, { "package": "dplyr", "role": "Imports" }, { "package": "readr", "version": ">= 0.2.2", "role": "Imports" }, { "package": "lazyeval", "role": "Imports" }, { "package": "PopED", "role": "Imports" }, { "package": "magrittr", "role": "Imports" }, { "package": "rlang", "role": "Imports" }, { "package": "purrr", "role": "Imports" }, { "package": "tibble", "role": "Imports" }, { "package": "rmarkdown", "role": "Imports" }, { "package": "tidyr", "role": "Imports" }, { "package": "ggplot2", "version": ">= 2.0.0", "role": "Imports" }, { "package": "grid", "role": "Imports" }, { "package": "gridExtra", "version": ">= 2.0.0", "role": "Imports" }, { "package": "grDevices", "role": "Imports" }, { "package": "stats", "role": "Imports" }, { "package": "bookdown", "role": "Imports" }, { "package": "testthat", "role": "Suggests" } ], "_owner": "uupharmacometrics", "_selfowned": true, "_usedby": 0, "_updates": [], "_tags": [], "_stars": 17, "_contributors": [ { "user": "andrewhooker", "count": 143, "uuid": 5432932 }, { "user": "chayan-acharya", "count": 91, "uuid": 34095571 }, { "user": "cacha0227", "count": 10, "uuid": 9989646 }, { "user": "rikardn", "count": 1, "uuid": 12795317 } ], "_userbio": { "uuid": 23479164, "type": "organization", "name": "Uppsala University, Pharmacometrics Research Group" }, "_downloads": { "count": 306, "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/ncappc" }, "_mentions": 1, "_devurl": "https://github.com/uupharmacometrics/ncappc", "_pkgdown": "https://uupharmacometrics.github.io/ncappc/", "_searchresults": 17, "_rbuild": "4.6.0", "_assets": [ "extra/citation.cff", "extra/citation.html", "extra/citation.json", "extra/citation.txt", "extra/contents.json", "extra/ncappc.html", "extra/NEWS.html", "extra/NEWS.txt", "extra/readme.html", "extra/readme.md", "manual.pdf" ], "_homeurl": "https://github.com/uupharmacometrics/ncappc", "_realowner": "uupharmacometrics", "_cranurl": true, "_releases": [ { "version": "0.1", "date": "2015-03-04" }, { "version": "0.2", "date": "2015-07-16" }, { "version": "0.2.1.0", "date": "2015-12-08" }, { "version": "0.2.1.1", "date": "2016-02-17" }, { "version": "0.3.0", "date": "2018-08-24" }, { "version": "1.0.0", "date": "2025-04-25" } ], "_exports": [ "calc.stat", "dv.plot", "est.nca", "histobs.plot", "histpop.plot", "nca.check.obs", "nca.check.sim", "nca.deviation.plot", "nca.ind.data", "nca.npde", "nca.npde.plot", "nca.pde.deviation.outlier", "nca.read.sim", "ncappc", "out.digits", "read_nm_table" ], "_help": [ { "page": "calc.stat", "title": "Calculates a set of statistics for a given array of numbers.", "topics": [ "calc.stat" ] }, { "page": "dv.plot", "title": "Plots drug plasma concentration vs time data", "topics": [ "dv.plot" ] }, { "page": "est.nca", "title": "Estimate individual NCA metrics.", "topics": [ "est.nca" ] }, { "page": "histobs.plot", "title": "Plots histogram of selected set of NCA metrics.", "topics": [ "histobs.plot" ] }, { "page": "histpop.plot", "title": "Plots population histogram of the NCA metrics selected for model diagnosis.", "topics": [ "histpop.plot" ] }, { "page": "nca_ind_data", "title": "Prepare individual PK data", "topics": [ "nca_ind_data" ] }, { "page": "nca.check.obs", "title": "Check observed data", "topics": [ "nca.check.obs" ] }, { "page": "nca.check.sim", "title": "Check simulated data", "topics": [ "nca.check.sim" ] }, { "page": "nca.deviation.plot", "title": "Plot individual deviation of NCA metrics estimated from observed and simulated data", "topics": [ "nca.deviation.plot" ] }, { "page": "nca.ind.data", "title": "Prepare individual PK data", "topics": [ "nca.ind.data" ] }, { "page": "nca.npde", "title": "Calculates individual normalized prediction distribution errors (NPDE) from PDE data.", "topics": [ "nca.npde" ] }, { "page": "nca.npde.plot", "title": "Plots population histogram of the NCA metrics selected for model diagnosis.", "topics": [ "nca.npde.plot" ] }, { "page": "nca.pde.deviation.outlier", "title": "Calculates individual prediction distribution errors (PDE) and scaled deviation of NCA metrics estimated from observed and simulated data. Identifies outlier to population PK model.", "topics": [ "nca.pde.deviation.outlier" ] }, { "page": "nca.read.sim", "title": "Check observed data", "topics": [ "nca.read.sim" ] }, { "page": "ncappc", "title": "Performs NCA calculations and population PK model diagnosis.", "topics": [ "ncappc" ] }, { "page": "out.digits", "title": "output value with correct digits and trailing zero", "topics": [ "out.digits" ] }, { "page": "read_nm_table", "title": "Read NONMEM table files produced.", "topics": [ "read_nm_table" ] } ], "_readme": "https://github.com/uupharmacometrics/ncappc/raw/HEAD/README.md", "_rundeps": [ "base64enc", "bit", "bit64", "bookdown", "boot", "bslib", "cachem", "cli", "clipr", "codetools", "cpp11", "crayon", "digest", "dplyr", "evaluate", "farver", "fastmap", "fontawesome", "fs", "generics", "ggplot2", "glue", "gridExtra", "gtable", "gtools", "highr", "hms", "htmltools", "isoband", "jquerylib", "jsonlite", "knitr", "labeling", "lazyeval", "lifecycle", "magrittr", "MASS", "memoise", "mime", "mvtnorm", "pillar", "pkgconfig", "plyr", "PopED", "prettyunits", "progress", "purrr", "R6", "rappdirs", "RColorBrewer", "Rcpp", "readr", "reshape2", "rlang", "rmarkdown", "S7", "sass", "scales", "stringi", "stringr", "tibble", "tidyr", "tidyselect", "tinytex", "tzdb", "utf8", "vctrs", "viridisLite", "vroom", "withr", "xfun", "xtable", "yaml" ], "_vignettes": [ { "source": "ncappc-vignette.Rmd", "filename": "ncappc-vignette.html", "title": "Introduction to the ncappc package", "author": "Chayan Acharya, Andrew C. Hooker, Siv Jönsson, Mats O. Karlsson", "engine": "knitr::rmarkdown", "headings": [ "Introduction", "Estimated NCA metrics", "Estimation method", "Output", "Tabular output", "ncaOutput.tsv", "ObsStat.tsv", "SimStat.tsv", "ncaSimData.tsv", "ncaSimEst.tsv", "Graphical output", "[Individual level] Concentration vs. time profile", "[Population level] Histogram of the selected NCA metrics estimated from the observed data", "[Population level] Histogram of the simulated population means of the NCA metrics", "[Individual level] Deviation of the simulated NCA metrics from the observed value", "[Individual level] Distribution of the simulated NCA metrics for the outliers}", "[Population level] Histogram of the NPDE values of the NCA metrics within a given population group", "[Population level] Forest plot for the NPDE type analysis", "[Individual level] NPDE values of the NCA metrics for each individual" ], "created": "2015-02-25 10:06:09", "modified": "2018-06-07 08:45:28", "commits": 11 } ], "_score": 5.63698910181223, "_indexed": true, "_nocasepkg": "ncappc", "_universes": [ "uupharmacometrics", "andrewhooker" ], "_binaries": [ { "r": "4.7.0", "os": "linux", "version": "1.0.0.9000", "date": "2026-05-24T08:18:28.000Z", "distro": "noble", "commit": "071bb256d8057ef9934e5dbd88d7d0b27705acf8", "fileid": "98249d709a41332b4117b4af1496c7212005b22829d76f1623149b90ea398874", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/uupharmacometrics/actions/runs/26356039488" }, { "r": "4.6.0", "os": "linux", "version": "1.0.0.9000", "date": "2026-05-24T08:18:31.000Z", "distro": "noble", "commit": "071bb256d8057ef9934e5dbd88d7d0b27705acf8", "fileid": "e793cb82d51ed025356ad1dc61b97f6f426768c601dabb31fba060452b3eb123", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/uupharmacometrics/actions/runs/26356039488" }, { "r": "4.5.3", "os": "mac", "version": "1.0.0.9000", "date": "2026-05-24T08:18:00.000Z", "commit": "071bb256d8057ef9934e5dbd88d7d0b27705acf8", "fileid": "7e928bd5b12c03fc2fcaf8f7cf0ae2593ad13869ab4b3243888c859a35dbc917", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/uupharmacometrics/actions/runs/26356039488" }, { "r": "4.6.0", "os": "mac", "version": "1.0.0.9000", "date": "2026-05-24T08:18:15.000Z", "commit": "071bb256d8057ef9934e5dbd88d7d0b27705acf8", "fileid": "7d75dd4b9fc3713c2bd31dcce59bbcc177fddf89af2f1eb0393e5cc29a1db291", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/uupharmacometrics/actions/runs/26356039488" }, { "r": "4.6.0", "os": "wasm", "version": "1.0.0.9000", "date": "2026-05-24T08:18:56.000Z", "commit": "071bb256d8057ef9934e5dbd88d7d0b27705acf8", "fileid": "74f63c8fc7e861fcaf3fcd7c68550b34e4728f6c3b5f1a28f8809826af4ce42c", "status": "success", "buildurl": "https://github.com/r-universe/uupharmacometrics/actions/runs/26356039488" }, { "r": "4.7.0", "os": "win", "version": "1.0.0.9000", "date": "2026-05-24T08:17:27.000Z", "commit": "071bb256d8057ef9934e5dbd88d7d0b27705acf8", "fileid": "d7155e1a70b9106d5ea86aa5559f2945bd90f33b8b31f928846f908388e07183", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/uupharmacometrics/actions/runs/26356039488" }, { "r": "4.5.3", "os": "win", "version": "1.0.0.9000", "date": "2026-05-24T08:17:27.000Z", "commit": "071bb256d8057ef9934e5dbd88d7d0b27705acf8", "fileid": "1e3765382734d6e80ce259b010df1d6393ccea729810182d48ec16bd330b1547", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/uupharmacometrics/actions/runs/26356039488" }, { "r": "4.6.0", "os": "win", "version": "1.0.0.9000", "date": "2026-05-24T08:17:28.000Z", "commit": "071bb256d8057ef9934e5dbd88d7d0b27705acf8", "fileid": "2c03d0c7d174137384a7dc587a677b0c85fd5b3f3370892b3af7497e4f6d17e4", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/uupharmacometrics/actions/runs/26356039488" } ] }